Virginia Union University faces long odds Tuesday, Oct. 23, when Coach Jay Butler’s Panthers play powerhouse Duke University in an exhibition basketball game in Durham, N.C.

Tipoff is 7 p.m. at Cameron Indoor Stadium on Duke’s campus.

The Blue Devils have won five NCAA titles and been runners-up on six occasions. VUU has won three NCAA Division II crowns, most recently in 2004.

Since 2010, Duke has agreed to face the CIAA champion in what amounts to a preseason practice game. Results haven’t been favorable for CIAA teams. The Blue Devils are 8-0 in the series, with eight blowouts.

VUU claimed the CIAA title last winter in Charlotte, N.C., but lost most of its firepower to graduation.

Duke was 29-8 last year but lost three stars — Marvin Bagley, Wendell Carter and Grayson Allen — in the first round of the NBA draft.

Duke’s top newcomer is Zion Williamson, the nation’s No. 1 ranked high school player in the Class of 2018.